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Trends of the Epidemiology of Candidemia in Switzerland: A 15-Year FUNGINOS Survey.

Trends of the Epidemiology of Candidemia in Switzerland: A 15-Year FUNGINOS Survey.

Authors :
Adam, Kai-Manuel
Osthoff, Michael
Lamoth, Frédéric
Conen, Anna
Erard, Véronique
Boggian, Katia
Schreiber, Peter W
Zimmerli, Stefan
Bochud, Pierre-Yves
Neofytos, Dionysios
Fleury, Mapi
Fankhauser, Hans
Goldenberger, Daniel
Mühlethaler, Konrad
Riat, Arnaud
Zbinden, Reinhard
Kronenberg, Andreas
Quiblier, Chantal
Marchetti, Oscar
Khanna, Nina
Source :
Open Forum Infectious Diseases; Oct2021, Vol. 8 Issue 10, p1-9, 9p
Publication Year :
2021

Abstract

Background The increasing incidence of candidemia and emergence of drug-resistant Candida species are major concerns worldwide. Long-term surveillance studies are needed. Methods The Fungal Infection Network of Switzerland (FUNGINOS) conducted a 15-year (2004–2018), nationwide, epidemiological study of candidemia. Hospital-based incidence of candidemia, Candida species distribution, antifungal susceptibility, and consumption were stratified in 3 periods (2004–2008, 2009–2013, 2014–2018). Population-based incidence over the period 2009–2018 derived from the Swiss Antibiotic Resistance Surveillance System (ANRESIS). Results A total of 2273 Candida blood isolates were studied. Population and hospital-based annual incidence of candidemia increased from 2.96 to 4.20/100 000 inhabitants (P =.022) and 0.86 to 0.99/10 000 patient-days (P =.124), respectively. The proportion of Candida albicans decreased significantly from 60% to 53% (P =.0023), whereas Candida glabrata increased from 18% to 27% (P <.0001). Other non- albicans Candida species remained stable. Candida glabrata bloodstream infections occurred predominantly in the age group 18–40 and above 65 years. A higher proportional increase of C glabrata was recorded in wards (18% to 29%, P <.0001) versus intensive care units (19% to 24%, P =.22). According to Clinical and Laboratory Standards Institute, nonsusceptibility to fluconazole in C albicans was observed in 1% of isolates, and anidulafungin and micafungin nonsusceptibility was observed in 2% of C albicans and C glabrata. Fluconazole consumption, the most frequently used antifungal, remained stable, whereas use of mold-active triazoles and echinocandins increased significantly in the last decade (P <.0001). Conclusions Over the 15-year period, the incidence of candidemia increased. A species shift toward C glabrata was recently observed, concurring with increased consumption of mold-active triazoles. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23288957
Volume :
8
Issue :
10
Database :
Complementary Index
Journal :
Open Forum Infectious Diseases
Publication Type :
Academic Journal
Accession number :
153478469
Full Text :
https://doi.org/10.1093/ofid/ofab471