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Trends of the Epidemiology of Candidemia in Switzerland: A 15-Year FUNGINOS Survey.
Trends of the Epidemiology of Candidemia in Switzerland: A 15-Year FUNGINOS Survey.
- Source :
- Open Forum Infectious Diseases; Oct2021, Vol. 8 Issue 10, p1-9, 9p
- Publication Year :
- 2021
-
Abstract
- Background The increasing incidence of candidemia and emergence of drug-resistant Candida species are major concerns worldwide. Long-term surveillance studies are needed. Methods The Fungal Infection Network of Switzerland (FUNGINOS) conducted a 15-year (2004–2018), nationwide, epidemiological study of candidemia. Hospital-based incidence of candidemia, Candida species distribution, antifungal susceptibility, and consumption were stratified in 3 periods (2004–2008, 2009–2013, 2014–2018). Population-based incidence over the period 2009–2018 derived from the Swiss Antibiotic Resistance Surveillance System (ANRESIS). Results A total of 2273 Candida blood isolates were studied. Population and hospital-based annual incidence of candidemia increased from 2.96 to 4.20/100 000 inhabitants (P =.022) and 0.86 to 0.99/10 000 patient-days (P =.124), respectively. The proportion of Candida albicans decreased significantly from 60% to 53% (P =.0023), whereas Candida glabrata increased from 18% to 27% (P <.0001). Other non- albicans Candida species remained stable. Candida glabrata bloodstream infections occurred predominantly in the age group 18–40 and above 65 years. A higher proportional increase of C glabrata was recorded in wards (18% to 29%, P <.0001) versus intensive care units (19% to 24%, P =.22). According to Clinical and Laboratory Standards Institute, nonsusceptibility to fluconazole in C albicans was observed in 1% of isolates, and anidulafungin and micafungin nonsusceptibility was observed in 2% of C albicans and C glabrata. Fluconazole consumption, the most frequently used antifungal, remained stable, whereas use of mold-active triazoles and echinocandins increased significantly in the last decade (P <.0001). Conclusions Over the 15-year period, the incidence of candidemia increased. A species shift toward C glabrata was recently observed, concurring with increased consumption of mold-active triazoles. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANDIDEMIA
MYCOSES
CANDIDA albicans
INTENSIVE care units
EPIDEMIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 23288957
- Volume :
- 8
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Open Forum Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 153478469
- Full Text :
- https://doi.org/10.1093/ofid/ofab471