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Inflammatory hydrocephalus.
- Source :
- Child's Nervous System; Nov2021, Vol. 37 Issue 11, p3341-3353, 13p
- Publication Year :
- 2021
-
Abstract
- Reparative inflammation is an important protective response that eliminates foreign organisms, damaged cells, and physical irritants. However, inappropriately triggered or sustained inflammation can respectively initiate, propagate, or prolong disease. Post-hemorrhagic (PHH) and post-infectious hydrocephalus (PIH) are the most common forms of hydrocephalus worldwide. They are treated using neurosurgical cerebrospinal fluid (CSF) diversion techniques with high complication and failure rates. Despite their distinct etiologies, clinical studies in human patients have shown PHH and PIH share similar CSF cytokine and immune cell profiles. Here, in light of recent work in model systems, we discuss the concept of "inflammatory hydrocephalus" to emphasize potential shared mechanisms and potential therapeutic vulnerabilities of these disorders. We propose that this change of emphasis could shift our thinking of PHH and PIH from a framework of life-long neurosurgical disorders to that of preventable conditions amenable to immunomodulation. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYDROCEPHALUS
CEREBROSPINAL fluid
CYTOKINES
CHOROID plexus
Subjects
Details
- Language :
- English
- ISSN :
- 02567040
- Volume :
- 37
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Child's Nervous System
- Publication Type :
- Academic Journal
- Accession number :
- 153475772
- Full Text :
- https://doi.org/10.1007/s00381-021-05255-z