Back to Search
Start Over
Factors Associated With a Persistent Seronegative Status 1 Year After a SARS-CoV-2 Massive Infection Outbreak in Community Dwellers Living in Rural Ecuador: A Prospective Population-based Study.
- Source :
- Journal of Primary Care & Community Health; 10/29/2021, Vol. 12, p1-8, 8p
- Publication Year :
- 2021
-
Abstract
- Background: The SARS-CoV-2 pandemic is affecting millions of people living in rural areas of Low- and Middle-Income Countries and is causing an already anticipated devastating effect on the health and economics of these populations. More information is needed to modify behaviors that may counterbalance the consequences of mass spread of the virus in these underserved communities. This study aimed to identify factors associated with a persistent SARS-CoV-2 seronegative status 1 year after a massive infection outbreak in middle-aged and older adults living in rural Ecuador. Methods: Individuals enrolled in the Atahualpa Project Cohort as of March 2020 received 5 rounds of tests for determination of SARS-CoV-2 antibodies in blood. Individuals who remained seronegative up to April 2021 were considered "persistently seronegative." An adjusted Poisson regression model was fitted to estimate the incidence risk ratio of factors directly or inversely associated with a persistent seronegative status. Results: A total of 673 individuals received baseline tests. Thirty-one declined consent or died and 429 seroconverted, leaving 213 seronegative subjects. Average SARS-CoV-2 incidence rate was 9.87 events (95% C.I.: 8.91-10.83) per 100 person-months of observation. The use of flushing toilet systems (instead of open latrines) increased 1.5 times the possibility of remaining seronegative. Likewise, every additional bedroom in the house increased by 15% the possibility of remaining seronegative. In contrast, every additional person in the house and having high cholesterol levels significantly reduced the possibility of remaining seronegative. Conclusions: The use of flushing toilet systems and the number of bedrooms in the house directly influenced the possibility of remaining seronegative among individuals living in this rural setting. Study results also demonstrated a sustained transmission of the virus even after a significant proportion of the population has been infected. Our findings reinforce the mass spread of SARS-CoV-2 in rural communities. [ABSTRACT FROM AUTHOR]
- Subjects :
- STATISTICS
BLOOD pressure
FASTING
CARDIOVASCULAR diseases risk factors
COVID-19
IMMUNOGLOBULINS
CONFIDENCE intervals
HERD immunity
RURAL conditions
SERODIAGNOSIS
RESTROOMS
AGE distribution
HYPERCHOLESTEREMIA
FISHER exact test
REGRESSION analysis
DISEASE incidence
DIET
BLOOD sugar
RISK assessment
SOCIOECONOMIC factors
PHYSICAL activity
SLEEP
SEX distribution
INDEPENDENT living
INFECTIOUS disease transmission
RESEARCH funding
ALCOHOL drinking
SCALE analysis (Psychology)
CHI-squared test
DESCRIPTIVE statistics
WAIST circumference
MEDICALLY underserved areas
COVID-19 testing
VIRAL antibodies
RESIDENTIAL patterns
DATA analysis software
ODDS ratio
SMOKING
BODY mass index
COVID-19 pandemic
LONGITUDINAL method
CHOLESTEROL
DISEASE risk factors
MIDDLE age
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 21501319
- Volume :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of Primary Care & Community Health
- Publication Type :
- Academic Journal
- Accession number :
- 153309680
- Full Text :
- https://doi.org/10.1177/21501327211054989