Back to Search Start Over

Team approach to polypharmacy evaluation and reduction: study protocol for a randomized controlled trial.

Authors :
Mangin, Dee
Lamarche, Larkin
Agarwal, Gina
Banh, Hoan Linh
Dore Brown, Naomi
Cassels, Alan
Colwill, Kiska
Dolovich, Lisa
Farrell, Barbara
Garrison, Scott
Gillett, James
Griffith, Lauren E.
Holbrook, Anne
Jurcic-Vrataric, Jane
McCormack, James
O'Reilly, Daria
Raina, Parminder
Richardson, Julie
Risdon, Cathy
Savelli, Mat
Source :
Trials; 10/26/2021, Vol. 22 Issue 1, p1-15, 15p, 1 Diagram, 2 Charts
Publication Year :
2021

Abstract

<bold>Background: </bold>Polypharmacy in older adults can be associated with negative outcomes including falls, impaired cognition, reduced quality of life, and general and functional decline. It is not clear to what extent these are reversible if the number of medications is reduced. Primary care does not have a systematic approach for reducing inappropriate polypharmacy, and there are few, if any, approaches that account for the patient's priorities and preferences. The primary objective of this study is to test the effect of TAPER (Team Approach to Polypharmacy Evaluation and Reduction), a structured operationalized clinical pathway focused on reducing inappropriate polypharmacy. TAPER integrates evidence tools for identifying potentially inappropriate medications, tapering, and monitoring guidance and explicit elicitation of patient priorities and preferences. We aim to determine the effect of TAPER on the number of medications (primary outcome) and health-related outcomes associated with polypharmacy in older adults.<bold>Methods: </bold>We designed a multi-center randomized controlled trial, with the lead implementation site in Hamilton, Ontario. Older adults aged 70 years or older who are on five or more medications will be eligible to participate. A total of 360 participants will be recruited. Participants will be assigned to either the control or intervention arm. The intervention involves a comprehensive multidisciplinary medication review by pharmacists and physicians in partnership with patients. This review will be focused on reducing medication burden, with the assumption that this will reduce the risks and harms of polypharmacy. The control group is a wait list, and control patients will be given appointments for the TAPER intervention at a date after the final outcome assessment. All patients will be followed up and outcomes measured in both groups at baseline and 6 months.<bold>Discussion: </bold>Our trial is unique in its design in that it aims to introduce an operationalized structured clinical pathway aimed to reduce polypharmacy in a primary care setting while at the same time recording patient's goals and priorities for treatment.<bold>Trial Registration: </bold>Clinical Trials.gov NCT02942927. First registered on October 24, 2016. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17456215
Volume :
22
Issue :
1
Database :
Complementary Index
Journal :
Trials
Publication Type :
Academic Journal
Accession number :
153221407
Full Text :
https://doi.org/10.1186/s13063-021-05685-9