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Antibody Testing of Infants Born to Asymptomatic COVID-19 Positive Mothers.
- Source :
- Neonatology Today; Oct2021, Vol. 16 Issue 10, p3-7, 5p
- Publication Year :
- 2021
-
Abstract
- Importance and Contribution of this Study: Variability exists in the passage of SARS-COV-2 IgG from asymptomatic COVID-19 mothers to their newly born infants. Awareness of SARS-COV-2 IgG may contribute to the management of asymptomatic RT PCR COVID-19 positive pregnant women, their newborns, and future vaccination practices. Objective: Characterize COVID testing results of asymptomatic COVID-19 positive pregnant women and their infants. Our assumption/hypothesis maintained that all infants born to asymptomatic COVID-19 positive mothers would have detectable SARS-CoV-2 specific IgG. Study Design: Retrospective chart review. Clinical demographics/COVID-19 testing of maternal/infant dyads were reviewed/collected for reporting purposes. Setting: Center for Women and Infants (CWI), University of Louisville Hospital, Louisville, KY. Participants: Asymptomatic COVID-19 positive pregnant women/infant dyads admitted to the CWI between June 2020 to February 2021. Results: 36 COVID-19 positive asymptomatic mother/37 infant dyads (one set of twins) reviewed. 38% of the mother/infant dyads were positive for SARS-CoV-2 IgG, while 27% of mother/infant dyads were negative for IgG. A COVID-19 positive mother of twins was IgG negative, but both twins were positive. Two mothers in this study group had developed significant COVID-19 disease at 28w4d gestation and 34w0d gestation. Both required intensive care but recovered, and their pregnancies were maintained until 37w4d and 39w3d gestation, respectively. By the time of delivery, both mothers had negative COVID-19 RT PCR testing, but both infants were positive for SARS-CoV-2 IgG antibodies. COVID-19 RT PCR testing on both of these infants at 24 and 48 hours of age was negative. Conclusion: SARS-CoV-2 IgG is passively transferred to the infant during pregnancy of asymptomatic positive COVID-19 mothers however appears variable and/or possibly based on the ability of IgG detection with current testing. Further investigation of the immune system's response to the SARS-CoV-2 virus during pregnancy can direct future management/treatment during pregnancy, especially in the wake of vaccination for the virus during pregnancy and emerging variants. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19
ANTIBODY titer
SARS-CoV-2
MOTHERS
INFANTS
CHILDBIRTH
MATERNAL health services
MATERNAL-child health services
REVERSE transcriptase polymerase chain reaction
IMMUNOGLOBULINS
MATERNAL-fetal exchange
ACADEMIC medical centers
SERODIAGNOSIS
CHEMILUMINESCENCE assay
RESEARCH methodology
PREGNANT women
RETROSPECTIVE studies
ACQUISITION of data
GESTATIONAL age
CORDOCENTESIS
MEDICAL records
IMMUNITY
DESCRIPTIVE statistics
COVID-19 testing
VIRAL antibodies
VERTICAL transmission (Communicable diseases)
CHILDREN
PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 19327129
- Volume :
- 16
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Neonatology Today
- Publication Type :
- Academic Journal
- Accession number :
- 153214921
- Full Text :
- https://doi.org/10.51362/neonatology.today/202110161037