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Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor.
- Source :
- Journal of Nanobiotechnology; 10/25/2021, Vol. 19 Issue 1, p1-12, 12p
- Publication Year :
- 2021
-
Abstract
- Background: Pancreatic ductal adenocarcinoma (PDAC) is a devastatingly malignant tumor with a high mortality. However, current strategies to treat PDAC generally have low efficacy and high side-effects, therefore, effective treatment against PDAC remains an urgent need. Results: We report a semiconducting polymer nano-radiopharmaceutical with intrinsic photothermal capability and labeling with therapeutic radioisotope <superscript>177</superscript>Lu (<superscript>177</superscript>Lu-SPN-GIP) for combined radio- and photothermal therapy of pancreatic tumor. <superscript>177</superscript>Lu-SPN-GIP endowed good stability at physiological conditions, high cell uptake, and long retention time in tumor site. By virtue of combined radiotherapy (RT) and photothermal therapy (PTT), <superscript>177</superscript>Lu-SPN-GIP exhibited enhanced therapeutic capability to kill cancer cells and xenograft tumor in living mice compared with RT or PTT alone. More importantly, <superscript>177</superscript>Lu-SPN-GIP could suppress the growth of the tumor stem cells and reverse epithelial mesenchymal transition (EMT), which may greatly reduce the occurrence of metastasis. Conclusion: Such strategy we developed could improve therapeutic outcomes over traditional RT as it is able to ablate tumor with relatively lower doses of radiopharmaceuticals to reduce its side effects. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14773155
- Volume :
- 19
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Nanobiotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 153205740
- Full Text :
- https://doi.org/10.1186/s12951-021-01083-0