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Down-regulated placental miR-21 contributes to preeclampsia through targeting RASA1.
- Source :
- Hypertension in Pregnancy; Aug 2021, Vol. 40 Issue 3, p236-245, 10p
- Publication Year :
- 2021
-
Abstract
- Human placenta was obtained from early onset preeclampsia, late onset preeclampsia, and their gestational age-matched normal pregnancy. Using RT-qPCR, western blot, and immunohistochemistry, it was demonstrated that miR-21 expressions were significantly decreased in preeclampsia while RASA1 were increased. Suppression of miR-21 in placental HTR-8/SVneo cells, remarkably upregulated RASA1, decreased proliferation, inhibited invasion, and promoted apoptosis of trophoblast cells, while overexpression of miR-21 alleviated these effects. Dual-luciferase reporter assays revealed RASA1 to be a direct target of miR-21 in trophoblast cells. miR-21 may serve key roles in the development of preeclampsia by targeting RASA1. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREECLAMPSIA
MICRORNA
PLACENTA
GENE expression
APOPTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 10641955
- Volume :
- 40
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Hypertension in Pregnancy
- Publication Type :
- Academic Journal
- Accession number :
- 153205531
- Full Text :
- https://doi.org/10.1080/10641955.2021.1974031