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Antibody Response to SARS-CoV-2: A Cohort Study in Qatar's Primary Care Settings.
- Source :
- Journal of Primary Care & Community Health; 10/19/2021, Vol. 12, p1-5, 5p
- Publication Year :
- 2021
-
Abstract
- Background: Globally, countries are rolling out Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) quarantine policies and vaccination programs. Research studies are needed in helping understand the likelihood of acquired immunity to reinfection and identify priority groups for vaccination to inform them. This study aimed to assess period prevalence and longitudinal changes in antibody levels after SARS-CoV-2 infection in Qatari primary care settings. Methods: A cohort study design with 2 data collection phases was undertaken—Phase 1 (conducted in July 2020) and Phase 2 (conducted in October 2020). A stratified random sampling technique by age, gender and nationality was utilized to identify the study sample. The total sample size required for the study was estimated to be 2102. Participants were invited to an appointment where they were administered a questionnaire and provided samples for polymerase chain reaction and Immunoglobulin G immunoassay tests. Results: A total of 943 individuals participated in both Phase 1 and Phase 2. In this cohort, seroprevalence of SARS-CoV-2 was found to be 12% (N = 113) in Phase 1 and 17.2% (N = 162) in Phase 2. Of the 113 participants who were seropositive in Phase 1, 38.1% (CI 29.5-47.2%, N = 43) had a reduction, 54.9% (CI 45.7-63.8%, N = 62) had no change, and 7.1% (CI 3.4-12.9%, N = 8) had an increase in IgG titer in Phase 2. All (N = 18) participants aged 10 to 17 years retained their antibodies. The proportion of men who retained their antibodies was slightly higher compared to women—92.5% (N = 74) and 87.9% (N = 29) respectively. Similarly, symptomatic individuals (97.8%; N = 45) had a higher antibody retention compared with asymptomatic individuals (86.4%; N = 57). Conclusions: This study provides preliminary information on the longitudinal changes in antibody levels after SARS-CoV-2 infection. These findings will help inform quarantine policies and vaccination programs. [ABSTRACT FROM AUTHOR]
- Subjects :
- HOSPITALS
REVERSE transcriptase polymerase chain reaction
RESEARCH
SEROPREVALENCE
STATISTICS
COVID-19
SAMPLE size (Statistics)
IMMUNOGLOBULINS
ACQUISITION of data methodology
CONFIDENCE intervals
HUMAN research subjects
PATIENT selection
AGE distribution
BLOOD collection
DISEASE incidence
ANTIBODY formation
PRIMARY health care
IMMUNOASSAY
COMPARATIVE studies
NOSE
SEX distribution
RESEARCH funding
QUESTIONNAIRES
MEDICAL records
DISEASE prevalence
DESCRIPTIVE statistics
STATISTICAL sampling
POLYMERASE chain reaction
DATA analysis software
DATA analysis
LONGITUDINAL method
OROPHARYNX
Subjects
Details
- Language :
- English
- ISSN :
- 21501319
- Volume :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of Primary Care & Community Health
- Publication Type :
- Academic Journal
- Accession number :
- 153101968
- Full Text :
- https://doi.org/10.1177/21501327211050569