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Undetectable thyroglobulin makes 123I whole-body scan and stimulated thyroglobulin obsolete in follow-up care of differentiated thyroid cancer: a retrospective study.
- Source :
- Thyroid Research; 10/19/2021, Vol. 14 Issue 1, p1-7, 7p
- Publication Year :
- 2021
-
Abstract
- Background: Differentiated thyroid cancer (DTC) is a common malignancy with increasing incidence. Follow-up care for DTC includes thyroglobulin (Tg) measurement and ultrasound (US) of the neck, combined with <superscript>131</superscript>I remnant ablation when indicated. Diagnostic precision has evolved with the introduction of the new high-sensitive Tg-assays (sensitivity ≤0.1 ng/mL). The aim of the study was to determine the prognostic utility of high-sensitive Tg and the need for other diagnostic tests in DTC. Methods: This was a retrospective, observational study. Patients with pathologically confirmed DTC, treated with total thyroidectomy and <superscript>131</superscript>I remnant ablation, who had their complete follow-up care in our institution were selected (October 2013–December 2018). Subjects with possible thyroglobulin autoantibody interference were excluded. Statistical analysis was performed using the IBM SPSS® Statistics 24 software package. Results: Forty patients were eligible for analysis. A total of 24 out of the 40 patients (60%) had an undetectable high-sensitive Tg 6 months after total thyroidectomy. None of these patients had a stimulated Tg above 1 ng/mL, or remnant on the <superscript>123</superscript>I Whole-Body Scan (WBS) after 1 year of follow-up. Ultrasound of the neck, performed between 6 and 12 months postoperative, was negative in 21 out of the 24 patients. Conclusions: This study shows that an undetectable high-sensitive Tg can change the management of patients with DTC and decrease the use and need of stimulated Tg and <superscript>123</superscript>I WBS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17566614
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Thyroid Research
- Publication Type :
- Academic Journal
- Accession number :
- 153098865
- Full Text :
- https://doi.org/10.1186/s13044-021-00114-0