VP33.12: Melatonin and docosahexaenoic acid improve diminished oligodendrogenesis in a rabbit neurospheres model of fetal growth restriction.

To evaluate neuroprotective effects of docosahexaenoic acid (DHA), melatonin (MEL) and sialic acid (SA) or lactoferrin (LF) in an I in vitro i neurosphere model of fetal growth restriction (FGR). Finally, the I in vivo i administration of DHA and MEL, and not LF, presented a significant increase in the oligodendrocyte differentiation in comparison to untreated FGR neurospheres (4.7% in untreated FGR vs. [Extracted from the article]