Dermal Toxicity Study in Wistar Rats against Penoxsulam Herbicide.

Penoxsulam is new triazolopyrimidine sulfonamide herbicides; it is used to control annual grass and weeds in rice but it disrupts internally growing weeds in rice and inhibits the acetolactate synthase which is commonly found in plants. Sulfonamides drugs may also implicate in any allergic reactions in the body. In agricultural field farmers deals with various herbicides. Skin is the vital path of enter into the body for vulnerability situations and due to large surface area lot of chemicals infilterate the skin can metabolize foreign compound. As Rat and Human both have similar body plans and organs, therefore rat is used as the best model for biological scanning. The present study was conducted to determine the effect of repeated exposure of Penoxsulam herbicide for 28 days by topical route on the physiology of Wistar rats. This study evaluates that there was no clinical signs, skin reactions (Draize method) was noticed and no significant changes was observed in Bodyweight, Haematology, Biochemistry and Histopathology in treated groups after compared with control group of animals. Therefore, Penoxsulam at 1000 mg/kg body weight did not showed any adverse effect on skin to treated rats during the experimentation period. [ABSTRACT FROM AUTHOR]