Evaluation of Analgesic, Antipyretic and Antiinflammatory Potential of Parkinsonia aculeata. Linn Fruit.

The present study was aimed at evaluation of the analgesic, anti-inflammatory and antipyretic activity of total methanolic and aqueous extract of Fruit of P. aculeate Linn in mice and rats. The methanolic extract of P. aculeate L Fruit at a dose of 200 mg/kg body weight has shown significant analgesic, antipyretic and antiinflammatory activity as compared to aqueous extract. The result of hot plate indicated that the total methanolic extract shows a significant increase (P<0.01) in reaction time at 2 and 3 hours comparable to the reference drug Pentazocin but lesser (P<0.05) at 1 hr. The tail immersion and hot plate test reveal that this plant has high analgesic activity. This is because some form of error may be introduced with the animal handing while the test is being elicited. Both test show highest degree of analgesia in methanolic extract compared to aqueous extract. The total methanolic extract of P. aculeate L fruit at the a dose of 200 mg/kg body weight has shown significant (p<0.001) antipyretic activity as compared to aqueous extract, it has shown significant fall in body temperature up to 4h following its admistration. The antipyretic activity stared as early as 1h and the effect was maintain for 4h. The response was comparable to that antipyretic activity of paracetamol a standard antipyretic drug. Total methanolic extract significantly inhibited Carrageenin-induced paw oedemaas compared; it may be due to possible inhibition of lipooxygenase pathway. [ABSTRACT FROM AUTHOR]