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Head and neck osteosarcomas: Analysis of treatment trends and survival outcomes in the United States (2004–2016).
- Source :
- Head & Neck; Nov2021, Vol. 43 Issue 11, p3294-3305, 12p
- Publication Year :
- 2021
-
Abstract
- Background: Head and neck osteosarcoma (HNOS) is a rare primary bone tumor with limited data to guide treatment approaches. Methods: The NCDB was used to identify patients diagnosed with HNOS. Kaplan–Meier and Cox multivariate regression were used to examine the impact of each treatment on overall survival (OS). Results: We identified 821 patients diagnosed with HNOS. Utilization of neoadjuvant chemotherapy + surgery increased from zero cases in 2004 to 24% of cases in 2016. Among surgically treated patients, 5‐year OS was 55.8% (CI: 51.7–60.1%). No difference was seen in OS between each treatment cohort on multivariate analysis. However, neoadjuvant chemotherapy + surgery + adjuvant chemotherapy had improved 18‐month survival compared to surgery alone (95.8% vs. 78.5%, p = 0.031). Conclusions: Our study demonstrated no survival benefit in perioperative chemotherapy or radiation therapy; however, short‐term survival improvement in patients receiving both neoadjuvant and adjuvant chemotherapy displays promise and requires further investigation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10433074
- Volume :
- 43
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Head & Neck
- Publication Type :
- Academic Journal
- Accession number :
- 152949209
- Full Text :
- https://doi.org/10.1002/hed.26817