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Head and neck osteosarcomas: Analysis of treatment trends and survival outcomes in the United States (2004–2016).

Authors :
Shim, Timothy
Chillakuru, Yeshwant
Darwish, Christina
Chalif, Eric
Strum, David
Benito, Daniel A.
Mulcahy, Collin F.
Monfared, Ashkan
Source :
Head & Neck; Nov2021, Vol. 43 Issue 11, p3294-3305, 12p
Publication Year :
2021

Abstract

Background: Head and neck osteosarcoma (HNOS) is a rare primary bone tumor with limited data to guide treatment approaches. Methods: The NCDB was used to identify patients diagnosed with HNOS. Kaplan–Meier and Cox multivariate regression were used to examine the impact of each treatment on overall survival (OS). Results: We identified 821 patients diagnosed with HNOS. Utilization of neoadjuvant chemotherapy + surgery increased from zero cases in 2004 to 24% of cases in 2016. Among surgically treated patients, 5‐year OS was 55.8% (CI: 51.7–60.1%). No difference was seen in OS between each treatment cohort on multivariate analysis. However, neoadjuvant chemotherapy + surgery + adjuvant chemotherapy had improved 18‐month survival compared to surgery alone (95.8% vs. 78.5%, p = 0.031). Conclusions: Our study demonstrated no survival benefit in perioperative chemotherapy or radiation therapy; however, short‐term survival improvement in patients receiving both neoadjuvant and adjuvant chemotherapy displays promise and requires further investigation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10433074
Volume :
43
Issue :
11
Database :
Complementary Index
Journal :
Head & Neck
Publication Type :
Academic Journal
Accession number :
152949209
Full Text :
https://doi.org/10.1002/hed.26817