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Measuring respiratory symptoms in moderate/severe asthma: evaluation of a respiratory symptom tool, the E-RS®: COPD in asthma populations.
- Source :
- Journal of Patient-Reported Outcomes; 10/10/2021, Vol. 5 Issue 1, p1-14, 14p
- Publication Year :
- 2021
-
Abstract
- Background: Symptom constructs included in the Evaluating Respiratory Symptoms in Chronic Obstructive Pulmonary Disease (E-RS®: COPD) tool may be relevant to patients with asthma. The purpose of this study was to evaluate content validity and psychometric performance of the E-RS: COPD in moderate/severe asthma patients. Methods: Content validity of the E-RS: COPD was evaluated in patients with moderate/severe asthma using concept elicitation and cognitive debriefing interviews. Secondary analyses using data from two clinical trials in patients with moderate/severe asthma evaluated the factor structure of the E-RS: COPD plus two supplementary items (wheeze; shortness of breath with strenuous physical activity) and assessed psychometric properties of the tool, which will be referred to as E-RS®: Asthma when used in asthma populations. Results: Qualitative interviews (N = 25) achieved concept saturation for asthma respiratory symptoms. Concepts in the E-RS: COPD were relevant to patients and instructions were understood. Most patients (19/25; 76%) reported experiencing all concepts in the E-RS: COPD; no patients indicated missing symptoms. Secondary analyses of clinical trial data supported the original factor structure (RS-Total and three symptom-specific subscales). The two supplemental items did not fit with this factor structure and were not retained. RS-Total and subscale score reliability was high (internal consistency [α] > 0.70). Validity was demonstrated through significant (P < 0.0001) relationships with the St George's Respiratory Questionnaire (SGRQ) and Asthma Symptom Severity scale. E-RS: Asthma was responsive to change when evaluated using SGRQ, Patient Global Impression of Change and Asthma Quality of Life Questionnaire as anchors (P < 0.0001). Clinically meaningful change thresholds were also identified (RS-Total: − 2.0 units). Conclusions: The E-RS: Asthma is reliable and responsive for evaluating respiratory symptoms in patients with moderate/severe asthma. [ABSTRACT FROM AUTHOR]
- Subjects :
- INHALERS
SYMPTOMS
ASTHMA
CHRONIC obstructive pulmonary disease
ASTHMATICS
DYSPNEA
RESEARCH evaluation
RESEARCH methodology evaluation
HEALTH outcome assessment
SEVERITY of illness index
PATIENTS' attitudes
PSYCHOMETRICS
QUALITATIVE research
OBSTRUCTIVE lung diseases
FACTOR analysis
DESCRIPTIVE statistics
RESEARCH funding
QUESTIONNAIRES
SECONDARY analysis
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 25098020
- Volume :
- 5
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Patient-Reported Outcomes
- Publication Type :
- Academic Journal
- Accession number :
- 152928224
- Full Text :
- https://doi.org/10.1186/s41687-021-00338-6