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Finite Element Analysis for Biodegradable Dissolving Microneedle Materials on Skin Puncture and Mechanical Performance Evaluation.
- Source :
- Polymers (20734360); Sep2021, Vol. 13 Issue 18, p3043-3043, 1p
- Publication Year :
- 2021
-
Abstract
- In this study, a micro-molding technology was used to prepare the microneedles (MNs), while a texture analyzer was used to measure its Young's modulus, Poisson's ratio and compression breaking force, to evaluate whether the MNs can penetrate the skin. The effects of different materials were characterized by their ability to withstand stresses using the Structural Mechanics Module of COMSOL Multiphysics. Carboxymethylcellulose (CMC) was chosen as the needle formulation material with varying quantities of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and hyaluronic acid (HA) to adjust the viscosity, brittleness, hardness and solubility of the material. The results of both the experimental tests and the predictions indicated that the hardest tip material had a solids content of 15% ( w / w ) with a 1:2 ( w / w ) CMC: HA ratio. Furthermore, it was shown that a solid content of 10% ( w / w ) with a 1:5 ( w / w ) CMC: PVA ratio is suitable for making patches. The correlation between the mechanical properties and the different materials was found using the simulation analysis as well as the force required for different dissolving microneedles (DMNs) to penetrate the skin, which significantly promoted the research progress of microneedle transdermal drug delivery. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20734360
- Volume :
- 13
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- Polymers (20734360)
- Publication Type :
- Academic Journal
- Accession number :
- 152801868
- Full Text :
- https://doi.org/10.3390/polym13183043