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Trimetazidine offers myocardial protection in elderly coronary artery disease patients undergoing non-cardiac surgery: a randomized, double-blind, placebo-controlled trial.
- Source :
- BMC Cardiovascular Disorders; 10/1/2021, Vol. 21 Issue 1, p1-7, 7p
- Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Trimetazidine (TMZ) pretreatment protects cardiomyocytes during cardiac surgery. TMZ may protect elderly patients with ischaemic heart disease (IHD) undergoing non-cardiac surgery.<bold>Methods: </bold>This was a randomized, double-blind, placebo-controlled trial (registration #ChiCTR1900025018) of patients with IHD scheduled to undergo non-cardiac surgery at Shenzhen People's Hospital (Shenzhen, Guangdong Province, China) between June 2014 and September 2015, randomized to 60 mg TMZ or placebo 12 h before surgery. The primary endpoint was the occurrence of in-hospital cardiovascular events. The secondary endpoints were myocardial ischaemia on five-lead electrocardiogram (cECG), cardiac troponin I (cTnI) elevation, cardiac death, acute coronary events, heart failure, and arrhythmia requiring treatments.<bold>Results: </bold>Compared with the placebo group, the TMZ group showed a lower occurrence of in-hospital cardiovascular events (primary endpoint, 20.0% vs. 37.5%, P = 0.02), myocardial ischaemia (15.0% vs. 32.5%, P < 0.01), cTnI elevation (2.5% vs. 10%, P < 0.01), acute coronary events (10.0% vs. 20.0%, P < 0.05), heart failure (0% vs. 2.5%, P < 0.05), and arrhythmia requiring treatment (17.5% vs. 35.0%, P < 0.05). There was no acute myocardial infarction during the 30-day postoperative period.<bold>Conclusions: </bold>In elderly patients with IHD undergoing non-cardiac surgery, TMZ pretreatment was associated with myocardial protective effects. Trial registration The trial was prospectively registered at http://www.chictr.org.cn/showproj.aspx?proj=41909 with registration number [ChiCTR1900025018] (7/8/2019). [ABSTRACT FROM AUTHOR]
- Subjects :
- CORONARY artery disease
HEART failure
MYOCARDIAL ischemia
MYOCARDIAL infarction
TRIMETAZIDINE
MYOCARDIAL perfusion imaging
MYOCARDIAL reperfusion
PREVENTION of surgical complications
RESEARCH
OPERATIVE surgery
HETEROCYCLIC compounds
TIME
RESEARCH methodology
SURGICAL complications
EVALUATION research
TREATMENT effectiveness
COMPARATIVE studies
RANDOMIZED controlled trials
VASODILATORS
BLIND experiment
RESEARCH funding
STATISTICAL sampling
Subjects
Details
- Language :
- English
- ISSN :
- 14712261
- Volume :
- 21
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Cardiovascular Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 152764814
- Full Text :
- https://doi.org/10.1186/s12872-021-02287-w