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Heat sensitivity of a SARS-associated coronavirus introduced into plasma products.
- Source :
- Vox Sanguinis; Nov2004, Vol. 87 Issue 4, p302-303, 2p
- Publication Year :
- 2004
-
Abstract
- Various measures to inactivate/remove viruses have been implemented for manufacturing plasma-derived products. Here, we examined the heat inactivation ability of an agent of the severe acute respiratory syndrome (SARS), SARS coronavirus (CoV).The Frankfurt-1 strain of SARS-CoV was incorporated in manufacturing processes of several products by using samples collected immediately before liquid heat treatment at 60 °C.SARS-CoV was easily inactivated by this treatment for 60 min in all in-process samples. However, the different composition of the tested samples affected the heat sensitivity of the virus strain: the infectivity of the virus in Antithrombin III preparation still remained after heating for 30 min at 60 °C.If by rare chance SARS-CoV contaminates source plasma, there should be no or only minor risk of this virus infection, due to sufficient inactivation by the 60 °C 10 h liquid heating step, although we must pay attention to the composition used for blood product preparation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00429007
- Volume :
- 87
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Vox Sanguinis
- Publication Type :
- Academic Journal
- Accession number :
- 15275442
- Full Text :
- https://doi.org/10.1111/j.1423-0410.2004.00577.x