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Natural variation of the cardiac transcriptome in humans.
- Source :
- RNA Biology; Oct2021, Vol. 18 Issue 10, p1374-1381, 8p
- Publication Year :
- 2021
-
Abstract
- We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features compared to the rest of the genome, such as lower mRNA levels and shorter half-lives coupled to increased translation efficiency. We observed that these genes are mostly involved with immune response and have a pleiotropic effect on disease phenotypes, indicating that asymptomatic conditions contribute to the gene expression diversity of healthy individuals. [ABSTRACT FROM AUTHOR]
- Subjects :
- TRANSCRIPTOMES
PHENOTYPES
GENETIC variation
GENE expression
HEART ventricles
Subjects
Details
- Language :
- English
- ISSN :
- 15476286
- Volume :
- 18
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- RNA Biology
- Publication Type :
- Academic Journal
- Accession number :
- 152741041
- Full Text :
- https://doi.org/10.1080/15476286.2020.1857508