Editorial: New Methods for Red Blood Cell Research and Diagnosis.

Keywords: red blood cell; anemia; diagnostics; ektacytometry; next generation sequencing; metabolomics (OMICS); sickle cell disease; RBC membrane defects EN red blood cell anemia diagnostics ektacytometry next generation sequencing metabolomics (OMICS) sickle cell disease RBC membrane defects 1 3 3 10/01/21 20210929 NES 210929 The last few years have been a challenging and exciting period for the study of RBC pathophysiology and related defects associated with hemolytic anemia. Red blood cell, anemia, diagnostics, next generation sequencing, sickle cell disease, RBC membrane defects, ektacytometry, metabolomics (OMICS) The latter was assessed using the CMST and the authors postulate that this yet-undescribed RBC feature reflects RBC membrane health, and as such the CMST holds promise as a novel biomarker for clinical severity and phenotypic expression in HS. The method was able to establish the diagnosis in 74% of patients with a diagnostic workup based on laboratory testing, and in an additional 35% of patients that were undiagnosed after extensive hematologic investigations. [Extracted from the article]