Back to Search
Start Over
A real-world study on diagnosis and prognosis of light-chain cardiac amyloidosis in Southern China.
- Source :
- BMC Cardiovascular Disorders; 9/18/2021, Vol. 21 Issue 1, p1-10, 10p
- Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Light-chain cardiac amyloidosis (AL-CA) has been highly valued in developed countries, but in developing countries, the recognition and diagnosis of this condition is still limited. There are currently few reports on a large number of Chinese patients with AL-CA. The present study aimed to report real-world clinical characteristics and prognosis of AL-CA in China.<bold>Methods and Results: </bold>Consecutive patients with AL-CA diagnosed at the Second Xiangya Hospital of Central South University between June 2012 and September 2020 were reviewed. A total of 170 patients with AL-CA have been recruited, whose mean ages were 60.81ā±ā10.46. 70.59% of the patients were male. They were from eight provinces in southern China, 55.7% were referred patients, and 37.3% had been misdiagnosed previously. 64 (37.6%) patients received chemotherapy. The median survival time for patients with AL-CA was 8.00 months, and survival time for patients who received chemotherapy was 13.00 months, which was significantly longer than that of patients with palliative treatment (13.00 vs 6.00, pā=ā0.004).<bold>Conclusions: </bold>Although clinicians have improved their understanding of AL-CA in recent years, the prognosis of AL-CA is still poor, and the misdiagnosis rate and missed diagnosis rate are still very high in China. It is imperative to improve the recognition and early diagnosis of this condition, which may require multidisciplinary collaboration among cardiologists, hematologists and nephrologists. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712261
- Volume :
- 21
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Cardiovascular Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 152519314
- Full Text :
- https://doi.org/10.1186/s12872-021-02256-3