CLINICAL AND HISTOLOGICAL STUDY OF THE EFFECT PLATELET-RICH AND POOR-PLASMA THERAPEUTIC MODEL ON REGENERATION OF THE SCIATIC NERVE IN RABBITS.

There are very similarity in the types of plasma-based treatments: the platelet rich-plasma (PRP) and platelet poor-plasma (PPP). The both types have been established as an autologous source for therapeutic angiogenesis. and the both have two main ingredient: platelets and plasma, fifteen healthy mature male rabbits were divided randomly into three experimental groups: The first group which treated with PRP, the second group, which treated with PPP and the third was control group, the sciatic nerve in all treated animals were transected and served in treatment protocols through surgical procedure after the nerve suture. Then all animals were followed up clinically for fourteen days, and histologically for sixty days after the operations. The results either clinically or histologically indicated that the treatment with PRP has remarkable beneficial effects on nerve healing represented acceleration and improvement of the nerve through reduce adhesion, increase nerve regenerations time and improve nerve function. However, the PRP treated groups were progressed than the PPP and control groups, by findings, demonstrated early weight bearing with fastest healing process. [ABSTRACT FROM AUTHOR]