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The Selective Antibacterial Activity of the Mixed Systems Containing Myristic Acid against Staphylococci.

The Selective Antibacterial Activity of the Mixed Systems Containing Myristic Acid against Staphylococci.

Authors :
Minako Okukawa
Yuika Yoshizaki
Shigekazu Yano
Yoshimune Nonomura
Source :
Journal of Oleo Science; 2021, Vol. 70 Issue 9, p1239-1246, 8p
Publication Year :
2021

Abstract

Fatty acids and their derivatives are interesting cosmetic ingredients because they show the selective antibacterial activity against Staphylococcus aureus (S. aureus). However, the antibacterial activity in mixed systems containing several active ingredients is unclear because previous studies focused antibacterial systems containing one kind of fatty acid. In the present study, the minimal inhibitory concentration (MIC) and the fractional inhibitory concentration (FIC) were evaluated for myristic acid/lauric acid, myristic acid/palmitoleic acid, and myristic acid/lactic acid mixed systems to show the effect of the coexisting components on the selective antibacterial activity of myristic acid. In the myristic acid/palmitoleic acid mixed system, the antibacterial activity against S. aureus was enhanced by additive effect, whereas the antibacterial activity was not observed against S. epidermidis. On the other hand, the myristic acid/lauric acid mixed system showed antibacterial activity against S. epidermidis: Lauric acid impaired the selectivity of antibacterial activity of myristic acid. These results suggest that the selective activity of myristic acid varies with the additives. The present findings are useful for designing formulations of cosmetics and body cleansers containing myristic acid. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13458957
Volume :
70
Issue :
9
Database :
Complementary Index
Journal :
Journal of Oleo Science
Publication Type :
Academic Journal
Accession number :
152341709
Full Text :
https://doi.org/10.5650/jos.ess21090