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Mortality From Respiratory Syncytial Virus in Children Under 2 Years of Age: A Prospective Community Cohort Study in Rural Maharashtra, India.
- Source :
- Clinical Infectious Diseases; 2021 Supplement, Vol. 73, pS193-S202, 10p
- Publication Year :
- 2021
-
Abstract
- Background Although respiratory syncytial virus (RSV) is the most important viral cause of lower respiratory tract infection deaths in infants, there are few data on infant community deaths caused by RSV. Methods This was an active surveillance of children younger than 2 years of age in 93 villages, 5 primary health centers, and 3 hospitals serving these villages. Village health workers and counselors at the health facilities monitored all lower respiratory tract infections (LRTIs) in consented subjects. Children with severe, or very severe LRTIs and all who died, had nasopharyngeal swabs collected for detection of RSV by molecular methods. Results In the 12 134 subjects, there were 2064 episodes of severe LRTIs and 1732 of very severe LRTIs, of which 271 and 195, respectively, had RSV. Fifteen of 16 (94%) children with RSV died of LRTIs, 14 in the community and 1 in the hospital. The case fatality ratios for severe RSV LRTIs in the first 6 months of life were 3/52 (7.1%) and 1/36 (2.8%) in the community and hospital, respectively. Of those with very severe LRTIs in the community, 17.6% died. There were no very severe RSV LRTI hospital deaths. The adjusted RSV LRTI mortality rates ranged from 1.0 to 3.0/1000 child-years (CY) overall, and 2.0 to 6.1/1000 CY, accounting for 20% of the LRTI deaths and 10% of the postneonatal infant mortality. Conclusions Community deaths from RSV account for the majority of RSV LRTI deaths, and efforts at prevention should be preferentially directed at populations where access to care is limited. [ABSTRACT FROM AUTHOR]
- Subjects :
- PUBLIC health surveillance
RESEARCH
HOSPITALS
MOLECULAR probes
HEALTH services accessibility
RURAL conditions
RESPIRATORY infections
MEDICAL cooperation
COMMUNITY health services
SEVERITY of illness index
HOSPITAL mortality
PREVENTIVE health services
DESCRIPTIVE statistics
RESPIRATORY syncytial virus infections
INFANT mortality
LONGITUDINAL method
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 73
- Database :
- Complementary Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 152286438
- Full Text :
- https://doi.org/10.1093/cid/ciab481