Study on the appropriate dose of dexmedetomidine leading analgesia combined with transverse abdominal plane block for postoperative analgesia in colon cancer.

Objective: To explore the suitable dosage of dexmedetomidine preemptive analgesia combined with transverse abdominal muscle block for postoperative analgesia of colon cancer. Methods: From March 2018 to October 2019, 120 patients undergoing laparoscopic radical resection of colon cancer in our hospital were randomly divided into control group (group C, without dexmedetomidine), low-dose group (group L, 0.5 μg/kg), medium-dose group (group M, 1 μg/kg) and high-dose group (group M, 0.5μ g/kg) The Mean arterial pressure, MAP), Heart rate, HR) and visual analog scale (vas) pain were compared at 2 h(T0), 4 h(T1), 8 h(T2), 12 h(T3), 24 h(T4) and 48 h(T5) after operation The pain sensitive area of mechanical stimulation was measured at T4, T5 and 72 h (T6) after operation. The adverse reactions of patients after operation were compared. Results: Compared with C group, MAP and HR of L, M and H groups decreased in different degrees at each time point. MAP and HR of m and h groups were lower than those of l group at different time points (P<0.05). The VAS score and pain sensitive area of T4-T6 in l, m and h groups were significantly lower than those in c group (P<0.05), but there was no significant difference in Ramsay score among groups (p > 0.05). The vas score and pain sensitive area of m and h groups were lower than those of l group (P<0.05). Incidence of postoperative adverse reactions in l, m and h groups was lower than that in c group (P<0.05). Conclusion: Dexmedetomidine at doses of 1 μg/kg and 1.5 μg/kg has a good analgesic effect without increasing the incidence of adverse reactions. It is recommended that 1 μg/kg Dexmedetomidine be used as an auxiliary drug dose of ropivacaine during TAP block. At the same time, it is necessary to strengthen monitoring to avoid adverse reactions such as hypotension and bradycardia. [ABSTRACT FROM AUTHOR]