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Chemo-Enzymatic Cascade for the Generation of Fragrance Aldehydes.

Authors :
Schwendenwein, Daniel
Ressmann, Anna K.
Entner, Marcello
Savic, Viktor
Winkler, Margit
Rudroff, Florian
Source :
Catalysts (2073-4344); Aug2021, Vol. 11 Issue 8, p932, 1p
Publication Year :
2021

Abstract

In this study, we present the synthesis of chiral fragrance aldehydes, which was tackled by a combination of chemo-catalysis and a multi-enzymatic in vivo cascade reaction and the development of a highly versatile high-throughput assay for the enzymatic reduction of carboxylic acids. We investigated a biocompatible metal-catalyzed synthesis for the preparation of α or β substituted cinnamic acid derivatives which were fed directly into the biocatalytic system. Subsequently, the target molecules were synthesized by an enzymatic cascade consisting of a carboxylate reduction, followed by the selective C-C double bond reduction catalyzed by appropriate enoate reductases. We investigated a biocompatible oxidative Heck protocol and combined it with cells expressing a carboxylic acid reductase from Neurospora crassa (NcCAR) and an ene reductase from Saccharomyces pastorianus for the production fragrance aldehydes. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734344
Volume :
11
Issue :
8
Database :
Complementary Index
Journal :
Catalysts (2073-4344)
Publication Type :
Academic Journal
Accession number :
152102442
Full Text :
https://doi.org/10.3390/catal11080932