Back to Search
Start Over
Cyclic Amplification of the Afterglow Luminescent Nanoreporter Enables the Prediction of Anti‐cancer Efficiency.
- Source :
- Angewandte Chemie; Sep2021, Vol. 133 Issue 36, p19932-19942, 11p
- Publication Year :
- 2021
-
Abstract
- We developed a cyclic amplification method for an organic afterglow nanoreporter for the real‐time visualization of self‐generated reactive oxygen species (ROS). We promoted semiconducting polymer nanoparticles (PFODBT) as a candidate for emitting near‐infrared afterglow luminescence. Introduction of a chemiluminescent substrate (CPPO) into PFODBT (PFODBT@CPPO) resulted in a significant enhancement of afterglow intensity through the dual cyclic amplification pathway involving singlet oxygen (1O2). 1O2 produced by PFODBT@CPPO induced cancer cell necrosis and promoted the release of damage‐related molecular patterns, thereby evoking immunogenic cell death (ICD)‐associated immune responses through ROS‐based oxidative stress. The afterglow luminescent signals of the nanoreporter were well correlated with light‐driven 1O2 generation and anti‐cancer efficiency. This imaging strategy provides a non‐invasive tool for predicting the therapeutic outcome that occurs during ROS‐mediated cancer therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELL death
REACTIVE oxygen species
OXIDATIVE stress
LUMINESCENCE
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 133
- Issue :
- 36
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 152096334
- Full Text :
- https://doi.org/10.1002/ange.202104127