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GABA B Receptor-Mediated Regulation of Dendro-Somatic Synergy in Layer 5 Pyramidal Neurons.
- Source :
- Frontiers in Cellular Neuroscience; 8/25/2021, Vol. 15, p1-19, 19p
- Publication Year :
- 2021
-
Abstract
- Synergistic interactions between independent synaptic input streams may fundamentally change the action potential (AP) output. Using partial information decomposition, we demonstrate here a substantial contribution of synergy between somatic and apical dendritic inputs to the information in the AP output of L5b pyramidal neurons. Activation of dendritic GABA<subscript> B </subscript> receptors (GABA<subscript> B </subscript>Rs), known to decrease APs in vivo , potently decreased synergy and increased somatic control of AP output. Synergy was the result of the voltage-dependence of the transfer resistance between dendrite and soma, which showed a two-fold increase per 28.7 mV dendritic depolarization. GIRK channels activated by dendritic GABA<subscript> B </subscript>Rs decreased voltage-dependent transfer resistances and AP output. In contrast, inhibition of dendritic L-type Ca<superscript>2+</superscript> channels prevented high-frequency bursts of APs, but did not affect dendro-somatic synergy. Finally, we show that NDNF-positive neurogliaform cells effectively control somatic AP via synaptic activation of dendritic GIRK channels. These results uncover a novel inhibitory mechanism that powerfully gates cellular information flow in the cortex. [ABSTRACT FROM AUTHOR]
- Subjects :
- PYRAMIDAL neurons
NEURAL inhibition
CALCIUM channels
Subjects
Details
- Language :
- English
- ISSN :
- 16625102
- Volume :
- 15
- Database :
- Complementary Index
- Journal :
- Frontiers in Cellular Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 152094530
- Full Text :
- https://doi.org/10.3389/fncel.2021.718413