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Vonoprazan-Associated Gastric Mucosal Redness in Non-Helicobacter pylori-Infected and Helicobacter pylori-Eradicated Stomach.

Authors :
Kubo, Kimitoshi
Kimura, Noriko
Watanabe, Ryosuke
Higashino, Masayuki
Tsuda, Momoko
Kato, Mototsugu
Source :
Case Reports in Gastroenterology; May-Aug2021, Vol. 15 Issue 2, p751-758, 8p
Publication Year :
2021

Abstract

Vonoprazan-associated gastric mucosal redness is rare, and its endoscopic and pathological features remain poorly described. We report 4 cases of vonoprazan-associated gastric mucosal redness, that is, 2 cases each in non-Helicobacter pylori-infected and -eradicated stomach. In all cases, esophagogastroduodenoscopy demonstrated spotty and linear redness newly appearing in the greater curvature of the gastric body after initiation of vonoprazan but disappearing after its discontinuation. A tissue biopsy taken from the gastric mucosa with redness revealed various pathological findings and included inflammatory cell infiltration, parietal cell protrusions, oxyntic gland dilatations, congestion, focal hemorrhage with congestion beneath the basement membrane, and vacuolar degeneration of parietal cells. To our knowledge, this is the second report describing the endoscopic and pathological features of vonoprazan-associated gastric mucosal redness. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16620631
Volume :
15
Issue :
2
Database :
Complementary Index
Journal :
Case Reports in Gastroenterology
Publication Type :
Academic Journal
Accession number :
152062937
Full Text :
https://doi.org/10.1159/000518292