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Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
- Source :
- Journal of Alzheimer's Disease; 2021, Vol. 82 Issue 4, p1745-1754, 10p
- Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Little is known about the relationship between sarcopenia and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs).<bold>Objective: </bold>This study aimed to investigate this association among community-dwelling adults aged≥65 years from six LMICs.<bold>Methods: </bold>Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. These data were obtained in China, Ghana, India, Mexico, Russia, and South Africa in 2007-2010. Participants were considered to have sarcopenia if they had low skeletal muscle mass (i.e., lower skeletal mass index) and a weak handgrip strength. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Multivariable logistic regression analysis was conducted to assess associations.<bold>Results: </bold>The final analytical sample consisted of 12,912 individuals aged≥65 years with preservation in functional abilities without stroke (mean [standard deviation] age 72.2 [10.8] years; 45.2% males). The overall prevalence of sarcopenia and MCI were 11.3% and 18.1%, respectively. After adjusting for potential confounders, there was a positive association between sarcopenia and MCI in all countries (i.e., odds ratio [OR] > 1) with the exception of South Africa, and the overall estimate was OR = 1.60 (95% confidence interval [CI] = 1.32-1.93) with a low level of between-country heterogeneity (I2 = 0.0%).<bold>Conclusion: </bold>There was a positive association between sarcopenia and MCI in this sample of older adults living in LMICs. Causality should be assessed in future longitudinal research, while the utility of sarcopenia as a marker of MCI should also be investigated. [ABSTRACT FROM AUTHOR]
- Subjects :
- MILD cognitive impairment
MIDDLE-income countries
OLDER people
SARCOPENIA
LOGISTIC regression analysis
GRIP strength
RESEARCH
CROSS-sectional method
RESEARCH methodology
WORLD health
MEDICAL cooperation
EVALUATION research
COMPARATIVE studies
INDEPENDENT living
DISEASE prevalence
RESEARCH funding
DEVELOPING countries
POVERTY
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 82
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 151949929
- Full Text :
- https://doi.org/10.3233/JAD-210321