Editorial: Model-Based Evaluation of Antimicrobial Agents in Children.

Keywords: pharmacokinetics; pharmacometrics; developmental pharmacology; children; antimicrobial agents EN pharmacokinetics pharmacometrics developmental pharmacology children antimicrobial agents 1 3 3 08/18/21 20210816 NES 210816 Introduction Globally, the rational use of drugs in pediatrics has received more and more attention from the regulatory agencies and public health professionals, because pediatric patients have, together with pregnant women, the highest off-label drug use, which may lead to treatment failure due to underdosing or toxicity due to overdosing ([4]). Weight and serum creatinine were found to have a strong effect on drug exposure, and model-based individualized dosing regimens for patients with different weight and serum creatinine values were recommended. By using two dose-optimized indicators, C SB min sb and pharmacokinetics/pharmacodynamics (PK/PD) targets, they found that the standard dose regimen of three loading doses of 10 mg/kg every 12 h, followed by 6-10 mg/kg/day might result in underdosing, except for moderate infection with a standard loading dose. [Extracted from the article]