Back to Search Start Over

Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review).

Authors :
Dumitrache, Mihai-Daniel
Jieanu, Ana Stefania
Scheau, Cristian
Badarau, Ioana Anca
Popescu, George Denis Alexandru
Caruntu, Ana
Costache, Daniel Octavian
Costache, Raluca Simona
Constantin, Carolina
Neagu, Monica
Caruntu, Constantin
Source :
Experimental & Therapeutic Medicine; Sep2021, Vol. 22 Issue 3, pN.PAG-N.PAG, 1p
Publication Year :
2021

Abstract

Chronic obstructive pulmonary disease (COPD) and asthma are chronic respiratory diseases with high prevalence and mortality that significantly alter the quality of life in affected patients. While the cellular and molecular mechanisms engaged in the development and evolution of these two conditions are different, COPD and asthma share a wide array of symptoms and clinical signs that may impede differential diagnosis. However, the distinct signaling pathways regulating cough and airway hyperresponsiveness employ the interaction of different cells, molecules, and receptors. Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a major role in cough and airway inflammation. Consequently, its agonist, capsaicin, is of substantial interest in exploring the cellular effects and regulatory pathways that mediate these respiratory conditions. Increasingly more studies emphasize the use of capsaicin for the inhalation cough challenge, yet the involvement of TRPV1 in cough, bronchoconstriction, and the initiation of inflammation has not been entirely revealed. This review outlines a comparative perspective on the effects of capsaicin and its receptor in the pathophysiology of COPD and asthma, underlying the complex entanglement of molecular signals that bridge the alteration of cellular function with the multitude of clinical effects. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17920981
Volume :
22
Issue :
3
Database :
Complementary Index
Journal :
Experimental & Therapeutic Medicine
Publication Type :
Academic Journal
Accession number :
151877249
Full Text :
https://doi.org/10.3892/etm.2021.10349