Back to Search
Start Over
Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review).
- Source :
- Experimental & Therapeutic Medicine; Sep2021, Vol. 22 Issue 3, pN.PAG-N.PAG, 1p
- Publication Year :
- 2021
-
Abstract
- Chronic obstructive pulmonary disease (COPD) and asthma are chronic respiratory diseases with high prevalence and mortality that significantly alter the quality of life in affected patients. While the cellular and molecular mechanisms engaged in the development and evolution of these two conditions are different, COPD and asthma share a wide array of symptoms and clinical signs that may impede differential diagnosis. However, the distinct signaling pathways regulating cough and airway hyperresponsiveness employ the interaction of different cells, molecules, and receptors. Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a major role in cough and airway inflammation. Consequently, its agonist, capsaicin, is of substantial interest in exploring the cellular effects and regulatory pathways that mediate these respiratory conditions. Increasingly more studies emphasize the use of capsaicin for the inhalation cough challenge, yet the involvement of TRPV1 in cough, bronchoconstriction, and the initiation of inflammation has not been entirely revealed. This review outlines a comparative perspective on the effects of capsaicin and its receptor in the pathophysiology of COPD and asthma, underlying the complex entanglement of molecular signals that bridge the alteration of cellular function with the multitude of clinical effects. [ABSTRACT FROM AUTHOR]
- Subjects :
- OBSTRUCTIVE lung diseases
ASTHMA
TRP channels
COUGH
TRPV cation channels
SYMPTOMS
Subjects
Details
- Language :
- English
- ISSN :
- 17920981
- Volume :
- 22
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Experimental & Therapeutic Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 151877249
- Full Text :
- https://doi.org/10.3892/etm.2021.10349