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Serum Neurofilament Dynamics Predicts Cognitive Progression in de novo Parkinson's Disease.

Serum Neurofilament Dynamics Predicts Cognitive Progression in de novo Parkinson's Disease.

Authors :
Ma, Ling-Zhi
Zhang, Can
Wang, Han
Ma, Ya-Hui
Shen, Xue-Ning
Wang, Jian
Tan, Lan
Dong, Qiang
Yu, Jin-Tai
Source :
Journal of Parkinson's Disease; 2021, Vol. 11 Issue 3, p1117-1127, 11p
Publication Year :
2021

Abstract

Background: Neurofilament light (NfL) can reflect the extent of neuron/axon damage, thus providing an opportunity to examine the severity and progression of the diseases with such damage. Objective: Whether serum NfL can be used as an indicator to monitor the cognitive progress of de novo Parkinson's disease (PD) remains unclear. Methods: In this research, 144 healthy controls and 301 de novo PD patients from Parkinson's Progression Markers Initiative (PPMI) were recruited. Linear mixed effects models were used to examine the associations of baseline/longitudinal serum NfL with cognitive decline. Cox regression was used to detect cognitive progression in PD participants. Results: We found PD patients had higher serum NfL than controls at baseline (p = 0.031), and NfL increase was faster in PD group (p < 0.001). Both baseline serum NfL and its rate of change predicted measurable cognitive decline in early PD (MoCA, β= –0.014, p < 0.001; β= –0.002, p < 0.001, respectively). Additionally, we observed that NfL levels were also able to predict progression in different diagnostic groups and Amyloid- PD and Amyloid+PD groups. After an average follow-up of 6.37±1.84 years, the baseline NfL of the third tertile of high concentrations was associated with a future high risk of PD dementia (adjusted HR 6.33, 95% CI 2.62–15.29, p < 0.001). Conclusion: In conclusion, our results indicated that the serum NfL concentration could function as an easily accessible biomarker to monitor the severity and progression of cognitive decline in PD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18777171
Volume :
11
Issue :
3
Database :
Complementary Index
Journal :
Journal of Parkinson's Disease
Publication Type :
Academic Journal
Accession number :
151820649
Full Text :
https://doi.org/10.3233/JPD-212535