Synthesis and Cardiotropic Activity of bis-(2,3,4-Trimethoxybenzyl)Alkanediamines.

A new series of bis-(2,3,4-trimethoxybenzyl)alkanediamines were obtained. Their anti-ischemic and antiarrhythmic activities were studied. Replacement of the central N atom of the triazaalkane linker in the previously studied compound ALM-802 by a carbon atom and shortening of the linker length led to preservation of the cardiotropic activity spectrum of the corresponding compounds. The most active compounds among the new series were ALM-844 [N¹,N⁵-bis(2,3,4-trimethoxybenzyl)pentane-1,5-diamine dihydrochloride] and ALM-851 [N¹,N³-bis(2,3,4-trimethoxybenzyl)propane-1,4-diamine dihydrochloride]. [ABSTRACT FROM AUTHOR]