Back to Search
Start Over
Improving the diagnosis of AUS/FLUS thyroid nodules using an algorithm with combination of BRAFV600E mutation analysis and ultrasound pattern-based risk stratification.
- Source :
- Clinical Hemorheology & Microcirculation; 2021, Vol. 77 Issue 3, p273-285, 13p
- Publication Year :
- 2021
-
Abstract
- PURPOSE: To propose a diagnostic algorithm for improving the diagnosis of atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) thyroid nodules. METHODS: This study retrospectively enrolled 77 consecutive patients with 81 AUS/FLUS nodules who underwent preoperative BRAF<superscript>V600E</superscript> mutation analysis. A new diagnostic algorithm was proposed that BRAF<superscript>V600E</superscript> mutation analysis for the Fine-needle aspiration cytology specimen was firstly carried out, in which positive BRAF<superscript>V600E</superscript> mutation indicated malignancy and classification of the nodules with negative BRAF<superscript>V600E</superscript> mutation was further performed based on ultrasound pattern-based risk stratification of American Thyroid Association Guidelines. The diagnostic performance of the new diagnostic algorithm was evaluated. RESULTS: The sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the receiver operating characteristic curve (AUROC) of new diagnostic algorithm were 94.6%, 84.0%, 91.4%, 86.9%, 90.1%, and 0.893, respectively. The proposed diagnostic algorithm significantly increased the diagnostic performances (AUROC: 0.893 vs. 0.837 and 0.795), sensitivity (94.6% vs. 71.4% and 75.0%), and accuracy (90.1% vs. 79.0% and 77.8%) compared with BRAF<superscript>V600E</superscript> mutation analysis alone and ultrasound pattern-based risk stratification alone (all P < 0.05). CONCLUSION: The proposed diagnostic algorithm is helpful for improving the diagnosis of AUS/FLUS nodules, which might be as a routine approach. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13860291
- Volume :
- 77
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Clinical Hemorheology & Microcirculation
- Publication Type :
- Academic Journal
- Accession number :
- 151802748
- Full Text :
- https://doi.org/10.3233/CH-200985