Enhanced Non-Enzymatic Glucose Detection Using a Flower-Like NiCo2O4 Spheres Modified Electrode.

The development of non-enzymatic glucose detection method is of great significance in the clinical, biological and food sample analysis. In this work, a NiCo₂O₄-Nafion modified glassy carbon electrode was successfully fabricated which can rapidly detect glucose (<5 s) with high selectivity. Flower-like nanorod-shaped NiCo₂O₄ spheres were simply synthesized via an one-pot hydrothermal reaction which were characterized by scanning electron microscope and X-ray diffraction. The as-prepared NiCo₂O₄ and Nafion modified glassy carbon electrode showed remarkable electrochemical activity for glucose detection in both cyclic voltammetry and chronoamperometry measurements. The anodic current was linearly proportional to glucose concentration in a broad range from 0.1 to 1360 μM. The detection limit of our NiCo₂O₄−Nafion modified electrode was determined as 10 nM (S/N = 3). Finally, the modified electrode exhibited high stability, selectivity and reproducibility. The electrode has been successfully applied to detect glucose in real food samples. [ABSTRACT FROM AUTHOR]