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High Prevalence of Chronic Viral Hepatitis and Liver Fibrosis Among Mongols in Southern California.

Authors :
Fong, Tse-Ling
Lee, Brian T.
Chang, Mimi
Nasanbayar, Khishigsuren
Tsogtoo, Enkhjargal
Boldbaatar, Delgerbat
Dashdorj, Esugen D.
Clifford, Namuun E.
Dashdorj, Arghun N.
Bang, Bo-Ram
Chida, Takeshi
Lim, Carolina
Sugiyama, Masaya
Mizokami, Masashi
Dashdorj, Naranjargal J.
Liu, Ping
Glenn, Jeffrey S.
Dashdorj, Naranbaatar D.
Saito, Takeshi
Source :
Digestive Diseases & Sciences; Aug2021, Vol. 66 Issue 8, p2833-2839, 7p
Publication Year :
2021

Abstract

Background: Mongolia is a highly endemic region for chronic hepatitis B (HBV), hepatitis delta (HDV), and hepatitis C (HCV) infections. Aim of this study was to comprehensively characterize chronic viral hepatitis among Mongols living in Southern California. Methods: Three screening events were conducted between August and November 2018, with 528 adult Mongols tested for HBV and HCV. HBsAg (+) individuals (CHB) underwent additional testing for HDV RNA and anti-HDV. Liver tests, platelet count, and FibroScan™ were performed on CHB and chronic HCV (CHC) individuals. Results: Fifty-one out of 534 were HBsAg reactive (9.7%), and all were foreign-born. Mean age of CHB individuals was 37.8 (range 18–69) years. Forty-six out of 51 were HBeAg (–). HBV genotypes were exclusively D2 or A1. Twenty-one out of 51 (41.2%) were anti-HDV (+) and 17/51 (33.3%) were HDV RNA (+). HDV RNA (+) individuals had significantly higher ALT, fibrosis-4 score, and liver stiffness compared to HDV RNA (–) individuals. Incidence of advanced fibrosis was higher in HDV RNA (+) individuals (57% vs. 13%, p = 0.013). Forty-eight (9.1%) individuals were anti-HCV (+) and 19 (3.6%) were HCV RNA (+). Mean age of CHC individuals was 40.2 (range 28–71) years. Prevalence of anti-HCV (+) was higher among those born between 1945 and 1965 versus those born after 1965 (18.8% vs. 7.9%, p = 0.025). Genotype 1b was predominant. Incidence of cirrhosis was 7% among all participants. Conclusions: Mongols living in the USA are at high risk for CHB and CHC infections. One-third of CHB individuals had CHD superinfection with advanced fibrosis. Universal screening for viral hepatitis in Mongols in the USA is mandatory. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01632116
Volume :
66
Issue :
8
Database :
Complementary Index
Journal :
Digestive Diseases & Sciences
Publication Type :
Academic Journal
Accession number :
151525518
Full Text :
https://doi.org/10.1007/s10620-020-06499-6