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NIR‐Responsive Fe3O4@MSN@PPy‐PVP Nanoparticles as the Nano‐Enzyme for Potential Tumor Therapy.

Authors :
Jia, Chengzheng
Liu, Huiwen
Hu, Yunxia
Wu, Hang
Zhu, Chunping
Zhang, Yuxuan
Wang, Shige
Huang, Mingxian
Source :
ChemistrySelect; 7/7/2021, Vol. 6 Issue 25, p6564-6573, 10p
Publication Year :
2021

Abstract

Among various kinds of photothermal conversion materials, polypyrrole (PPy) has attracted ever‐increasing attention because of its good biocompatibility and excellent near‐infrared light response property. In this research, the core‐shell nanoparticles with magnetic Fe3O4 as the core and mesoporous silica (MSN) as the shell were prepared, the resulted Fe3O4@MSN nanoparticles were then surface coated with a layer of PPy and further modified with polyvinylpyrrolidone (PVP) to gain colloidal stability. The Fe2+ in Fe3O4 can catalyze the decomposition of H2O2 in tumor cells to produce cytotoxic hydroxyl radicals, thus realizing the tumor chemodynamic therapy. Meanwhile, the MSN layer gives the nanoparticles a higher drug loading capacity of chemotherapeutics (doxorubicin, DOX). Therefore, the prepared Fe3O4@MSN@PPy‐PVP nanoparticles not only have good biocompatibility, magnetism and colloidal stability but also can realize the combined tumor photothermal, chemo, and chemodynamic therapy. This study demonstrates the rational design of multifunctional nanoplatforms for biomedical applications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23656549
Volume :
6
Issue :
25
Database :
Complementary Index
Journal :
ChemistrySelect
Publication Type :
Academic Journal
Accession number :
151472064
Full Text :
https://doi.org/10.1002/slct.202101163