Transfusion‐transmitted infection and comorbidities in patients with severe haemophilia: A longitudinal birth cohort analysis.

A total of 93 (38.0%) persons with severe haemophilia had anti-HCV seropositivity, and 152 (62.0%) had anti-HCV seronegativity (Table 2). In comparison with era A (72.1%) when virus-inactivated CFC was available only in small groups of patients and serological screening for anti-HCV was just initiated in 1991, PWH in eras B and C had a significantly lower proportion of HCV infection. Keywords: comorbidity; haemophilia; HCV infection; transfusion-transmitted infection EN comorbidity haemophilia HCV infection transfusion-transmitted infection e458 e461 4 07/21/21 20210701 NES 210701 Haemophilia A (HA) and haemophilia B (HB) caused by mutations in the genes encoding clotting factor VIII and factor IX, respectively, are the most common inherited bleeding disorders.1 The mainstay of treatment for HA and HB is replacement of the missing clotting factors. Of the 4 PWH with HIV infection, all were co-infected with HCV infection. [Extracted from the article]