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Palladium-catalyzed cascade carbonylative annulation between alkene-tethered aryl iodides and carbon monoxide.
- Source :
- Chemical Communications; 7/21/2021, Vol. 57 Issue 57, p7023-7026, 4p
- Publication Year :
- 2021
-
Abstract
- Rapid construction of molecules bearing all-substituted quaternary stereocenters represents a highly significant but challenging task in organic synthesis. Herein, we report a novel palladium-catalyzed cascade between alkene-tethered aryl iodides and carbon monoxide, which has resulted in a practical and powerful method for the synthesis of complex polycyclic molecules containing aryl-substituted quaternary stereocenters. Mechanistic studies suggested that the reaction proceeded via a Heck-type carbonylative cyclization, followed by a ketene-involved Friedel–Crafts acylation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 57
- Issue :
- 57
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 151436555
- Full Text :
- https://doi.org/10.1039/d1cc02217b