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Psychometric properties of the thyroid-specific quality of life questionnaire ThyPRO in Singaporean patients with Graves' disease.
- Source :
- Journal of Patient-Reported Outcomes; 7/8/2021, Vol. 5 Issue 1, p1-12, 12p
- Publication Year :
- 2021
-
Abstract
- Background: Graves' disease is the most common cause of hyperthyroidism. It results in accelerated tissue metabolism with multi-organ involvement ranging from cardiovascular to neuropsychological function. This results in a negative impact on the quality of life (QOL) of the individual patient. We aim to evaluate the psychometric properties of ThyPRO, a Thyroid-related Patient Reported Outcome questionnaire, and validate its use in our multi-ethnic Asian patients with Graves' hyperthyroidism. Methods: Forty-seven consecutive Graves' hyperthyroidism patients answered the ThyPRO questionnaire at baseline and at 4 months after treatment initiation. Data were recorded for thyroid related symptoms and signs, thyroid function tests and thyroid volume. We analyzed the internal consistency using Cronbach's alpha, construct validity by evaluating relationship between clinical variables and ThyPRO scales, ceiling and floor effects, and responsiveness of ThyPRO to treatment based on Cohen's effect size. Results: Correlations between individual scale scores and free thyroxine concentrations were moderate and statistically significant: 0.21–0.64 (p < 0.05). There was high internal consistency between the items in this instrument, Cronbach's alpha > 0.7 for all scales. ThyPRO was responsive to the changes in QOL after treatment (Effect Size: 0.20–0.77) in 9 of the 14 scales including the hyperthyroid symptoms and psychosocial scales (Tiredness, Cognitive complaints, Anxiety, Emotional susceptibility, Impact on Social, Daily and Sex life). Conclusion: This study provides evidence that ThyPRO has satisfactory measurement properties in hyperthyroid Graves' disease patients in Singapore population with the potential to complement clinical care. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYPERTHYROIDISM
PSYCHOMETRICS
QUALITY of life
CLINICAL trials
QUESTIONNAIRES
THYROID gland function tests
COGNITION disorders
STATISTICAL significance
STATISTICS
HUMAN research subjects
RESEARCH evaluation
CONFIDENCE intervals
RESEARCH methodology evaluation
THYROXINE
EFFECT sizes (Statistics)
ONE-way analysis of variance
HEALTH outcome assessment
GRAVES' disease
INFORMED consent (Medical law)
CRONBACH'S alpha
MULTITRAIT multimethod techniques
DESCRIPTIVE statistics
RESEARCH funding
THYROID antagonists
ANXIETY
STATISTICAL correlation
DATA analysis software
DATA analysis
SYMPTOMS
Subjects
Details
- Language :
- English
- ISSN :
- 25098020
- Volume :
- 5
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Patient-Reported Outcomes
- Publication Type :
- Academic Journal
- Accession number :
- 151332689
- Full Text :
- https://doi.org/10.1186/s41687-021-00309-x