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Hepatitis E virus prevalence among blood donors in Dali, China.

Authors :
Fu, Ping
Lin, Baochai
Wu, Bingting
Ke, Ling
Yang, Tianfu
Du, Yue'e
Cheng, Lishan
Li, Zhou
Li, Tiancheng
Liu, Yu
Source :
Virology Journal; 7/7/2021, Vol. 18 Issue 1, p1-6, 6p
Publication Year :
2021

Abstract

Background: Hepatitis E virus (HEV) is a nonenveloped RNA virus causing hepatitis E worldwide. The increase in transfusion-transmitted cases of HEV infections from asymptomatic blood donors causing serious illnesses among immunosuppressed recipients has been reported in the past few years. China is one of the most prevalent regions of HEV; as a result, it is important to evaluate the risk of transfusion-transmitted HEV. Methods: A total of 1864 serum samples (including demographic characteristics) from blood donors were randomly collected from February to March 2018 in Dali city. Anti-HEV IgG, IgM and IgA antibodies and HEV antigen were examined by enzyme-linked immunosorbent assay (ELISA). HEV RNA was detected by real-time PCR. Multivariable logistic regression modelling was used to examine the risk factors associated with HEV prevalence. Results: Overall, the positive rates of anti-HEV IgG, IgM, and IgA antibodies were 13.36% (249/1864), 1.13% (21/1864), and 1.82% (34/1864), respectively. However, none of the 1864 serum samples were HEV antigen positive or HEV RNA positive. Females (16.69%) had a significantly higher HEV seroprevalence than males (13.04%) (odds ratio [OR] 1.34 [95% CI, 1.02–1.75]). Bai (18.85%) donors had a significantly higher HEV seroprevalence than Han (12.21%) blood donors (odds ratio [OR], 1.65 [95% CI, 1.24–2.19] for Bai). Conclusions: HEV showed a seroprevalence among blood donors in Yunnan Province, some of which were even recent infections, indicating a threat to the safety of blood transfusions. Whether to formulate a strategy for HEV screening in blood centres needs further research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1743422X
Volume :
18
Issue :
1
Database :
Complementary Index
Journal :
Virology Journal
Publication Type :
Academic Journal
Accession number :
151289776
Full Text :
https://doi.org/10.1186/s12985-021-01607-y