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Novel mumps virus epitopes reveal robust cytotoxic T cell responses after natural infection but not after vaccination.
- Source :
- Scientific Reports; 7/1/2021, Vol. 11 Issue 1, p1-7, 7p
- Publication Year :
- 2021
-
Abstract
- Mumps is nowadays re-emerging despite vaccination. The contribution of T cell immunity to protection against mumps has not been clearly defined. Previously, we described a set of 41 peptides that were eluted from human leukocyte antigen (HLA) class I molecules of mumps virus (MuV)-infected cells. Here, we confirmed immunogenicity of five novel HLA-B*07:02- and HLA-A*01:01-restricted MuV T cell epitopes from this set of peptides. High frequencies of T cells against these five MuV epitopes could be detected ex vivo in all tested mumps patients. Moreover, these epitope-specific T cells derived from mumps patients displayed strong cytotoxic activity. In contrast, only marginal T cell responses against these novel MuV epitopes could be detected in recently vaccinated persons, corroborating earlier findings. Identifying which MuV epitopes are dominantly targeted in the mumps-specific CD8<superscript>+</superscript> T- response is an important step towards better understanding in the discrepancies between natural infection or vaccination-induced cell-mediated immune protection. [ABSTRACT FROM AUTHOR]
- Subjects :
- MUMPS
CELL-mediated cytotoxicity
T cells
LEUCOCYTES
CD80 antigen
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 151208697
- Full Text :
- https://doi.org/10.1038/s41598-021-92926-1