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Design, Synthesis and Anticancer Activity of a New Series of N -aryl- N ′-[4-(pyridin-2-ylmethoxy)benzyl]urea Derivatives.

Authors :
Hou, Shicheng
Liang, Shishao
Zhang, Chao
Han, Yingmei
Liang, Jianhui
Hu, Hongyu
Zhang, Xingeng
Hu, Chun
Liu, Xiaoping
Zhang, Hong
Source :
Molecules; Jun2021, Vol. 26 Issue 12, p3496, 1p
Publication Year :
2021

Abstract

The development of cancer treatments requires continuous exploration and improvement, in which the discovery of new drugs for the treatment of cancer is still an important pathway. In this study, based on the molecular hybridization strategy, a new structural framework with an N-aryl-N'-arylmethylurea scaffold was designed, and 16 new target compounds were synthesized and evaluated for their antiproliferative activities against four different cancer cell lines A549, MCF7, HCT116, PC3, and human liver normal cell line HL7702. The results have shown seven compounds with 1-methylpiperidin-4-yl groups having excellent activities against all four cancer cell lines, and they exhibited scarcely any activities against HL7702. Among them, compound 9b and 9d showed greatly excellent activity against the four kinds of cells, and the IC<subscript>50</subscript> for MCF7 and PC3 cell lines were even less than 3 μM. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14203049
Volume :
26
Issue :
12
Database :
Complementary Index
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
151142411
Full Text :
https://doi.org/10.3390/molecules26123496