Identifying sodium non‐excretors: heart failure's emerging golden ticket for risk stratification.

B This article refers to 'Renal profiling based on estimated glomerular filtration rate and spot urine sodium identifies high-risk acute heart failure patients' by J. Biegus I et al i ., published in this issue on pages 729-739. b Every era grapples with a medical riddle and the complexities underlying the interaction between heart and kidney physiology are no exception, as knowledge gaps regarding this complex interaction have persisted throughout much of medical history. Secondly, some patients received intravenous diuretics in the pre-hospital setting or had intensification of oral diuretics prior to admission, which may have affected baseline U SB Na sb values. It is also unclear whether I all i patients will need serial assessment of U SB Na sb (for example, a patient who has >3 L/day of urine output is likely diuretic responsive). [Extracted from the article]