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Dual Control of Peptide Conformation with Light and Metal Coordination.
- Source :
- Chemistry - A European Journal; 6/21/2021, Vol. 27 Issue 35, p8956-8959, 4p
- Publication Year :
- 2021
-
Abstract
- The design of a stimuli‐responsive peptide whose conformation is controlled by wavelength‐specific light and metal coordination is described. The peptide adopts a defined tertiary structure and its conformation can be modulated between an α‐helical coiled coil and β‐sheet. The peptide is designed with a hydrophobic interface to induce coiled coil formation and is based on a recently described strategy to obtain switchable helix dimers. Herein, we endowed the helix dimer with 8‐hydroxyquinoline (HQ) groups to achieve metal coordination and shift to a β‐sheet structure. It was found that the conformational shift only occurs upon introduction of Zn2+; other metal ions (Cu2+, Fe3+, Co2+, Mg2, and Ni2+) do not offer switching likely due to non‐specific metal‐peptide coordination. A control peptide lacking the metal‐coordinating residues does not show conformational switching with Zn2+ supporting the role of this metal in stabilizing the β‐sheet conformation in a defined manner. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIGHT metals
TERTIARY structure
METAL ions
DIMERS
METALS
CONFORMATIONAL analysis
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 27
- Issue :
- 35
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 151004995
- Full Text :
- https://doi.org/10.1002/chem.202101006