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Gastrointestinal protein loss in children with portal hypertension.
- Source :
- Indian Journal of Gastroenterology; Jun2021, Vol. 40 Issue 3, p333-337, 5p
- Publication Year :
- 2021
-
Abstract
- Portal hypertension increases pressure in lymphatic ducts, which may lead to gastrointestinal (GI) protein loss. Reports have shown that adults with portal hypertension had resolution of protein-losing enteropathy after transplantation; but studies in children are very limited. We therefore aimed to evaluate GI protein loss in children with portal hypertension and defined changes after liver transplantation. Children aged 3 months to 18 years with portal hypertension and the age-matched healthy controls were enrolled during August 2018 to September 2019. Random fecal alpha-1 antitrypsin measurements were obtained at the initial visit, 3 months later, 1 week before, and 3 months after liver transplantation (if applicable). One or more positive test (> 0.795 mg/dL) was interpreted as a positive result. We enrolled 76 children (n = 38 in each group) with a median age of 15.5 months (interquartile range [IQR], 11.2–41.7), female 51%, and 92% with biliary atresia in the portal hypertension group. We noted GI protein loss in 4/38 children (10.5%) with portal hypertension, while none in the controls (p = 0.11). We found no significant differences on the markers of severity of liver disease and serum albumin between patients with vs. the ones without GI protein loss (p > 0.05). After liver transplantation, 2/4 patients with GI protein loss had undetectable loss. We found that, in a small group of children, 10.5% with portal hypertension had notable GI protein loss without significant relationships with the severity of liver disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02548860
- Volume :
- 40
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Indian Journal of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 150854378
- Full Text :
- https://doi.org/10.1007/s12664-020-01079-y