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TiO 2 Decorated Low-Molecular Chitosan a Microsized Adsorbent for a 68 Ge/ 68 Ga Generator System.
- Source :
- Molecules; Jun2021, Vol. 26 Issue 11, p3185, 1p
- Publication Year :
- 2021
-
Abstract
- We report column material for a <superscript>68</superscript>Ge/<superscript>68</superscript>Ga generator with acid resistance and excellent adsorption and desorption capacity of <superscript>68</superscript>Ge and <superscript>68</superscript>Ga, respectively. Despite being a core element of the <superscript>68</superscript>Ge/<superscript>68</superscript>Ga generator system, research on this has been insufficient. Therefore, we synthesized a low molecular chitosan-based TiO<subscript>2</subscript> (LC-TiO<subscript>2</subscript>) adsorbent via a physical trapping method as a durable <superscript>68</superscript>Ge/<superscript>68</superscript>Ga generator column material. The adsorption/desorption studies exhibited a higher separation factor of <superscript>68</superscript>Ge/<superscript>68</superscript>Ga in the concentration range of HCl examined (0.01 M to 1.0 M). The prepared LC-TiO<subscript>2</subscript> adsorbent showed acid resistance capabilities with >93% of <superscript>68</superscript>Ga elution yield and 1.6 × 10<superscript>−4</superscript>% of <superscript>68</superscript>Ge breakthrough. In particular, the labeling efficiency of DOTA and NOTA, by using the generator eluted <superscript>68</superscript>Ga, was quite encouraging and confirmed to be 99.65 and 99.69%, respectively. Accordingly, the resulting behavior of LC-TiO<subscript>2</subscript> towards <superscript>68</superscript>Ge/<superscript>68</superscript>Ga adsorption/desorption capacity and stability with aqueous HCl exhibited a high potential for ion-exchange solid-phase extraction for the <superscript>68</superscript>Ge/<superscript>68</superscript>Ga generator column material. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 150834420
- Full Text :
- https://doi.org/10.3390/molecules26113185