SARS‐CoV‐2 spike protein positivity in pityriasis rosea‐like and urticaria‐like rashes of COVID‐19.

SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19 Dear Editor, The spike protein of SARS-CoV-2 is responsible for receptor recognition and cell membrane fusion.1 Positive immunohistochemistry (IHC) for SARS-CoV/SARS-CoV-2 spike protein has been found in lungs, tracheal mucosa and renal tubular epithelial cells, and recently in chilblain-like and erythema multiforme-like lesions of patients with COVID-19.2 Herein we report on two patients, one with a pityriasis rosea-like rash and one with an urticarial rash, with positive IHC for SARS-CoV/SARS-CoV-2 spike protein. Six weeks earlier he presented COVID-19 infection (confirmed with SARS-CoV-2 reverse-transcriptase polymerase chain reaction); his symptoms included malaise, dysgeusia, anosmia and an urticarial rash. [Extracted from the article]