Association Between Nonsyndromic Cleft Lip and Palate and 2 Polymorphic Loci: A Meta-Analysis.

Objectives: The relationship between Noggin (NOG) and methylenetetrahydrofolate reductase and nonsyndromic cleft lip and palate (NSCLP) has been reported participate in craniofacial development but need further evidence. To indicate the susceptibility between the 2 genes and NSCLP, rs227731 and rs1801131 polymorphisms were included in the present research. This research may provide some genetic clues for disease detection and surveillance. Design: Seventeen studies including 4023 cases and 5691 controls were provided for meta-analysis, and odds ratio (OR) with 95% CI were obtained to estimate NSCLP risk. Results: Our analysis suggested potential association of rs227731C on increasing the risk of NSCLP in the Caucasian group and total group but not Asian group under all models: allele (OR = 1.45, 95% CI = 1.21-1.75, P <.0001), homozygote (OR = 2.03, 95% CI = 1.42-2.90, P <.0001), heterozygote (OR = 1.44, 95% CI = 1.19-1.73, P =.0001), dominant (OR = 1.61, 95% CI = 1.27-2.04, P <.0001), and recessive models (OR = 1.63, 95% CI = 1.25-2.12, P =.0003). Besides, increased risk is related to rs1801131 in Asian group under 3 models: allele (OR = 1.24, 95% CI = 1.06-1.44, P =.006), heterozygote (OR = 1.24, 95% CI = 1.02-1.52, P =.03), and dominant models (OR = 1.29, 95% CI = 1.06-1.56, P =.009). Conclusions: Our analysis indicates polymorphisms rs227731 and rs1801131 are associated with NSCLP, with predominance of different ethnic group and deepen understanding of NSCLP. [ABSTRACT FROM AUTHOR]