Potential compounds phenolic group sawo leaves (Manilkara zapota) as an α-amylase inhibitor in type 2 diabetes mellitus by in silico.

Diabetes mellitus is a disease caused by abnormalities in the pancreas due to impaired insulin secretion or the inability to use the insulin produced effectively, which treats hyperglycemia. Indonesia ranks 4 in the world with the highest number of diabetes mellitus sufferers, namely 8.4 million people, and will continue to increase to 21.2 million people in 2030. α-Amylase (alpha-1,4glucan-4-glucanohydrolase) is a catalyst hydrolyzing Alpha-1,4-glycosidic polysaccharides of starch become oligosaccharides then digested further to produce glucose. In controlling glucose in people with DMT2, it is necessary to consider the choice of oral antidiabetic drugs (OAD) because of their many side effects. The anti-diabetic activity of Sapodilla leaf extract (Manilkara zapota) has been proven to show real antidiabetic activity by showing a hypoglycemic effect. Phenolic compounds have biological activity as anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic. This study aimed to obtain a prediction of the antidiabetic potential of the phenolic compounds of Sapodilla leaf extract (Manilkara zapota) in inhibiting the α-Amylase enzyme in type 2 DM patients. The method used in this study was to predict the pharmacokinetics of ADMET using the online pkCSM webserver. At the outset, we downloaded a copy of the test of compound SMILES using the PubChem webserver, Molecular docking using PyRx 0.8, PyMol, and Discovery Studio software. The findings suggested that the phenolic group compounds are predicted to have good absorption, distribution, metabolism, excretion, and toxicity values, and the combination of free energy values of phenolic compounds produced a synergistic effect. The bond between sitagliptin and the α-amylase enzyme was the most stable domain compared to others. [ABSTRACT FROM AUTHOR]